Master the Basics First
The interventions in this section are not where you should start. Before exploring Level 3:
- Have you optimized your sleep?
- Is your diet dialed in?
- Are you exercising consistently?
- Have you explored Level 2 protocols?
If not, go back. The ROI here is lower than getting the fundamentals right.
Why Level 3?
These protocols are here because they fall into one or more categories:
- Emerging evidence: The science is promising but not yet definitive
- Higher complexity: They require more knowledge, tracking, or resources
- Precautionary: Worth considering to err on the side of caution, even without strong data
- Medical involvement: Some require physician oversight or prescription
Level 3 is not about being reckless—it’s about being informed on the frontier of longevity science.
The Protocols
Pharmaceutical Interventions
Drugs being studied or repurposed for longevity. These require medical supervision.
- Rapamycin: The most studied longevity drug, targeting mTOR to induce autophagy and mimic caloric restriction.
- Advanced Lipid Management: Going beyond standard cholesterol panels to ApoB, Lp(a), and aggressive cardiovascular risk reduction.
Emerging Therapies
Interventions at various stages of research and adoption.
- Hyperbaric Oxygen Therapy: Using pressurized oxygen to enhance healing and potentially reverse aging markers.
- Gene Therapy: The future of medicine—modifying genetic expression for health outcomes.
- Vibration Plates: Whole-body vibration for bone density and circulation.
Precautionary Protocols
Interventions where the evidence is thin, but the potential harm of not acting may be significant.
- Microplastics: The invisible threat in our food, water, and air. Limited data on long-term impacts, but reasonable precautions are low-cost.
The Philosophy of Level 3
These interventions should be approached with:
- Humility: We do not have all the answers yet
- Prioritization: Only after Levels 1 and 2 are solid
- Critical thinking: Evaluate the evidence yourself
- Appropriate caution: Some interventions here do require medical partnership
Explore with curiosity, but don’t neglect the fundamentals.